Explain the relationship between electron transport and oxidative phosphorylation. How do uncoupling proteins "uncouple" this relationship in brown adipose tissue?
Match the terms in the left column to the appropriate blanks in the sentences on the right. Terms can be used once, more than once, or not at all.
Terms:
the electron transport chain
reduction potential
inner membrane
proton gradient
electron gradient
oxidative phosphorylation
protons
electrons
complex IV
Sentences:
The electron transport chain is possible via a(n) __________ that is established in __________.
Uncoupling proteins disrupt this relationship by allowing __________ to freely pass through the __________, thus reducing the __________ and the production of ATP by __________.
Answer (2)
The electron transport chain creates a proton gradient that powers ATP synthesis in oxidative phosphorylation. Uncoupling proteins allow protons to bypass ATP synthase, reducing both the proton gradient and ATP production, while generating heat. This mechanism is crucial in brown adipose tissue for thermoregulation. ;
The electron transport chain establishes a proton gradient across the inner membrane, which is essential for ATP production during oxidative phosphorylation. Uncoupling proteins in brown adipose tissue allow protons to bypass ATP synthase, leading to reduced ATP production and increased heat generation. This mechanism is critical for thermoregulation.
;
