What is the reference for a peer-reviewed article on 'Does the dopamine hypothesis explain schizophrenia?'
Chi-Ieong Lau, Han-Cheng Wang, Jung-Lung Hsu, Mu-En Liu
PMID: 23843581 DOI: 10.1515/revneuro-2013-0011
Abstract:
The dopamine hypothesis has been the cornerstone in the research and clinical practice of schizophrenia. With the initial emphasis on the role of excessive dopamine, the hypothesis has evolved to a concept of combining prefrontal hypodopaminergia and striatal hyperdopaminergia, and subsequently to the present aberrant salience hypothesis. This article provides a brief overview of the development and evidence of the dopamine hypothesis. It will argue that the current model of aberrant salience explains psychosis in schizophrenia and provides a plausible linkage between the pharmacological and cognitive aspects of the disease. Despite the privileged role of dopamine hypothesis in psychosis, its pathophysiological rather than etiological basis, its limitations in defining symptoms other than psychosis, as well as the evidence of other neurotransmitters such as glutamate and adenosine, prompt us to a wider perspective of the disease. Finally, dopamine does explain the pathophysiology of schizophrenia, but not necessarily the cause per se. Rather, dopamine acts as the common final pathway of a wide variety of predisposing factors, either environmental, genetic, or both, that lead to the disease. Other neurotransmitters, such as glutamate and adenosine, may also collaborate with dopamine to give rise to the entire picture of schizophrenia.
Answer (2)
The reference you provided is for a peer-reviewed article discussing whether the dopamine hypothesis explains schizophrenia. Here's the complete citation you can use:
Lau, Chi-Ieong, et al. "Does the dopamine hypothesis explain schizophrenia?" The dopamine hypothesis has been the cornerstone in the research and clinical practice of schizophrenia. With evolving concepts from excessive dopamine focus to combining prefrontal hypodopaminergia and striatal hyperdopaminergia, and to the current aberrant salience hypothesis. The article argues that while the dopamine hypothesis plays a significant role in explaining psychosis, it doesn't fully address other aspects or causes of schizophrenia. As it stands, dopamine serves as a common pathway potentially involving various environmental and genetic factors, with additional contributions from neurotransmitters like glutamate and adenosine. Published in 2013. DOI: 10.1515/revneuro-2013-0011. PMID: 23843581.
The article investigates the dopamine hypothesis's role in explaining schizophrenia, detailing its evolution and current understanding. While it highlights dopamine's importance in psychosis, it critiques the hypothesis's limitations and advocates for considering other neurotransmitters like glutamate and adenosine. Ultimately, dopamine explains the disease's mechanisms but not all the underlying causes.
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