What might happen to a protein if homeostasis is disrupted? Why?
Answer (2)
Disruption in protein homeostasis leads to the appearance and accumulation of intermediate nonnative conformations that tend to form oligomeric and aggregated species, which over time cause cellular injury..
When homeostasis is disrupted, proteins may become denatured due to changes in conditions like temperature and pH. This can lead to their loss of function, impacting cellular processes and potentially resulting in diseases. For example, malfunctioning insulin proteins can lead to diabetes, a condition linked to homeostatic imbalance.
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